An important resource for finding biological databases is a special yearly issue of the journal Nucleic Acids Research (NAR). Biological databases offer access to a wide variety of biological data and play a central role in bioinformatics56 7. Originally they were just sequence collections, but they have grown to store different biological databases heavily interconnected and they provide powerful interfaces to search and browse the stored information. Bio-101 is an online database of life science protocols. • Data (genomic sequences, 3D structures, 2D gel analysis, MS analysis, Microarrays….) Law enforcement agencies use these databases to track collected evidence. Protocol Online protocol-online.org. Bioinformatics has its importance in the management and collection of biological data. Its mission is to make life science research more efficient and reproducible by curating and hosting high-quality, experimentally validated, freely accessible protocols. Biological databases play a central role in bioinformatics. They offer scientists the opportunity to access sequence and structure data for tens of thousands of sequences from a broad range of organisms. INTRODUCTION TO BIOLOGICAL DATABASES SARFARAZ HUSSAIN Department of Bioinformatics & Biotechnology GCU- Faisalabad NOTE: Most slides derived from NCBI’s field guide / sarfraz1412@gmail.com 2. Biological databases play a central role in bioinformatics. Nucleic Acids Research Database Issue. The distinction between the concepts of biological relevance and statistical significance should be A protein database is one or more datasets about proteins, which could include a protein’s amino acid sequence, conformation, structure, and … A DNA database is a stored set of genetic profiles that can be used for a variety of needs. Biological databases constitute the data layer of molecular biology and bioinformatics and are becoming a central component of some emerging fields such as clinical bioinformatics, and translational and personalized medicine. Confusion in the use of words such as “significance”, “relevance” and “importance” can therefore hinder the assessment. These databases may be public or private. Biological databases 1. Statistical analysis of the data is central to this assessment. Bioinformatics is the branch of science in which we use computer tools and algorithms to analyze biological data. are no longer published in a conventional manner, but directly submitted to databases. • Essential tools for biological research. EMBnet MCB, feb 2005 Distribution of databases assessment of the evidence provided by these studies. Why biological databases ? Baxevanis AD. 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