The cortical bone thickness of femurs was continuous, increasing gradually from the end to the middle part. Above this age, and you may need to create a new Wiley Online Library account. These fractures have a transverse or short oblique orientation, may be noncomminuted or minimally comminuted, and are associated with hypertrophy of the cortex in the shaft.2, 4 Although AFFs are extremely rare, Gedmintas and colleagues conducted a systematic review and meta‐analysis concerning the association of BP use with AFF and reported that there is a clear association between BP use and AFF, and the risk for AFF increases as the duration of BP use increases.3. Statistical t-tests were performed to evaluate differences in cortical thickness based on proximal femur region. Volume 3: Biomedical and Biotechnology Engineering. As a result, uNTX was measured in 285 patients and serum PINP was measured 312 patients in the control group. Washington, DC 20036-3309, USA Data were tested for normality, and, if not normal, were analyzed by nonparametric methods. Our results are consistent with those of the previous studies mentioned above. The age-related increase in Ct.Po is more than 2-fold greater in women than in men. The correlation (Spearman) of the results from the two assessments was also calculated as a measure of agreement. Use the link below to share a full-text version of this article with your friends and colleagues. Prevalence and Characteristics of Atypical Periprosthetic Femoral Fractures. Body mass index (BMI) and serum calcium concentration were higher in the BP group (Table 1), whereas height was lower in the BP group. V003T04A071. Conclusions: Cortical thickness captures bone deficits in individuals with DMD, and may be a promising noninvasive measure to include in studies of bone health in individuals with muscular dystrophy. Body mass index (BMI) and serum calcium concentration were higher in the BP group (Table 1), whereas height was lower in the BP group. 9). The ASBMR appointed a task force to summarize the current state of knowledge, and this group defined AFF according to five major features and four minor features.2 Because most of these features relate to postfracture conditions, it is difficult to evaluate these features before the occurrence of an AFF. All patients in their study demonstrated histomorphometric evidence of severely suppressed bone turnover. In addition, follow‐up radiographs were obtained at least 1 year after baseline measurements (mean 1.4 ± 0.3 years; range 1.0 to 2.3 years) to evaluate changes in the longitudinal cortical thickness with BP treatment. Moreover, cortical thickness remained stable after an additional year of continued BP use. Any p values <0.05 were considered statistically significant. The mean absolute difference and SD between measurements of intraobserver and interobserver variability were 0.2 ± 0.3 mm and 0.3 ± 0.3 mm, respectively. BMI = body mass index; NTX = N‐telopeptide; PINP = procollagen type I N‐terminal propeptide. Measurement reliability was evaluated using coefficient of variation, intraclass correlation coefficients, and overlap metrics. Differences in the FS diameter, cortical thickness, and cortical thickness ratio in the BP and control groups were assessed with the Mann–Whitney U‐test. The mean ages of the patients in the BP and control groups were 79 ± 9 years (mean [SD]) (range 52 to 99 years) and 79 ± 9 years (range 50 to 99 years), respectively. In conclusion, our study did not find evidence of cortical thickening at the ST/FS area of the femur with long‐term BP use. Even after careful comparisons, we did not observe an increase in the femoral cortical thickness in long‐term BP users compared with controls. November 11–17, 2016. 1, line AD). Please check your email for instructions on resetting your password. Incomplete atypical femoral fractures after bisphosphonate use in postmenopausal women. Cortical thickness was reviewed independently by orthopedic surgeons or well‐trained therapists who were blinded to patient characteristics. After a minimum of 1 year of additional BP use, we observed no significant change in cortical thickness or the cortical thickness ratio at any level of the femur, but a significant change in the region of maximal femoral cortical thickness was observed according to the results of Wilcoxon signed‐rank test (Table 3) and Bonferroni correction (data not shown). In conclusion, our study did not find evidence of cortical thickening at the ST/FS area of the femur with long‐term BP use. Differences in categorical variables were assessed with the chi‐square test and Fisher's exact test. As the Japanese Ministry of Health, Labour and Welfare approved daily teriparatide in October 2010, weekly terparatide in November 2011, and denosumab in March 2013, several patients who had received long‐term BP treatment switched to these drugs. We did not identify any cases of lateral cortical stress fracture. In relevance to the imaging of osteoarthritis (see EPOS#3971) This cortical thickness analysis technique also holds promise … MMs of cortical thickness facilitate visualization of the distribution of cortical bone in long bone diaphyses. Thereafter, two pairs of four points were plotted on the FS at each level of measurement. The reasons that subsequent radiographs were not obtained in some cases were as follows: 17 patients were lost to follow‐up; less than 1 year had passed since the initial evaluation for 13 patients; 12 patients switched to other drugs; 1 patient finished osteoporosis treatment; and 1 patient relocated. If you do not receive an email within 10 minutes, your email address may not be registered, The first limitation is related to study design. Distribution of bone density and cortical thickness in the proximal femur and their association with hip fracture in postmenopausal women: a quantitative computed tomography study. Effects of osteoporosis drug treatments on cortical and trabecular bone in the femur using DXA-based 3D modeling. Written informed consent was obtained from all patients. Femur bone of the newborn pups were collected, decalcified and processed for paraffin sectioning. We performed yearly X‐ray evaluations in the patients who had used BPs for more than 5 years since 2011 as part of routine care. Cortical bone is detected when the CT data exceeds a predetermined threshold; cortical thickness follows as the distance between points where the CT data crosses the threshold, and cortical density is the average of the CT values between these points. In one of several previous studies of cortical thickening in long‐term BP users, Beck and colleagues found that the mean cortical thickness ratio at the FS had increased by 1.82% after 24 months of alendronate use, whereas it had decreased by approximately 0.31% with placebo.18 In contrast, Unnanuntana and colleagues performed bone density scanning and reported that long‐term alendronate use did not alter cortical thickness on the basis of comparison with thicknesses in untreated controls.11 Koeppen and colleagues measured the femoral cortical thickness in 58 patients with AFF and 218 controls19 and reported no difference in the cortical thickness ratio between patients with AFF and controls. Cortical bone has been reported to be an important determinant of bone strength; so far, no genome-wide association studies (GWAS) have been … Additional Supporting Information may be found in the online version of this article. The location of maximal cortical thickness was variable, but was more anterior and less inferior in patients. Phone: +1 (202) 367-1161 © 2014 American Society for Bone and Mineral Research. We enrolled 142 patients (mean age 79 years) who had taken BPs for more than 5 years, and enrolled 426 osteoporosis patients who had not used BPs as controls. However, whether thickening precedes BP use or results from BP use, as well as the role BPs may play in cortical thickening remain unclear. In one of several previous studies of cortical thickening in long‐term BP users, Beck and colleagues found that the mean cortical thickness ratio at the FS had increased by 1.82% after 24 months of alendronate use, whereas it had decreased by approximately 0.31% with placebo.18 In contrast, Unnanuntana and colleagues performed bone density scanning and reported that long‐term alendronate use did not alter cortical thickness on the basis of comparison with thicknesses in untreated controls.11 Koeppen and colleagues measured the femoral cortical thickness in 58 patients with AFF and 218 controls19 and reported no difference in the cortical thickness ratio between patients with AFF and controls. By ELISA ( Alere Medical Co., Ltd., Tokyo, Japan ) Handels GmbH®, Deutschland is... Bone quality and dimensional parameters, at least temporally results from the cortical bone thickness femur assessments was calculated. 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